Posttranscriptional modification to the core of tRNAs modulates translational misreading errors.

RNA · 2023 · PMC10726164 · PMID 37907335

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may be significantno p-value reported

It may be significant that these two enzymes modify residues 46 and 48 of the extra loop of tRNA U U U L y s , implying a functional interaction between the two modifications in this region.

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highly significantno p-value reported

The activities produced from the mutant mRNAs are highly reproducible and quantitative, providing a highly significant estimate of any alterations to misreading frequency caused by mutations affecting various components of the translation system.

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