Single-cell methylation analysis of brain tissue prioritizes mutations that alter transcription.

Cell Genom · 2023 · PMC10726494 · PMID 38116123

Europe PMC DOI

hedged sentence

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp = 4.11e−18actually significant

There are higher D2:B6 ratios in the CpG high sequence density regions than in the low, and because there are so many more sites without mutations, the effect is highly significant (p = 4.11e−18), but the increase is much smaller than that found in regions with mutations (mean ratio in high: 0.034, mean ratio in low: −0.001).

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