Activation of CB2R by synthetic CB2R agonist, PM289, improves brain endothelial barrier properties, decreases inflammatory response and enhances endothelial repair.

NeuroImmune Pharm Ther · 2023 · PMC10726734 · PMID 38116176

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a slight trendno p-value reported

Stimulation and activation of hCMEC/D3 by 100 ng/mL of TNFα for 6 h shows a slight trend towards an increase in CNR1 but it is not statistically significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.