An APC of >0 for a given stage indicates an increasing trend in morbidity/mortality/DALY rates.
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Long-term trends in the burden of colorectal cancer in Europe over three decades: a joinpoint regression and age-period-cohort analysis.
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The sentences
Conversely, an APC of <0 for a stage represents a decreasing trend in morbidity/mortality/DALY rates ( 13 ).