The crucial role of single-stranded DNA binding in enhancing sensitivity to DNA-damaging agents for Schlafen 11 and Schlafen 13.

iScience · 2023 · PMC10730379 · PMID 38125019

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Despite the strong conservation of sequences and structures among SLFNs, SLFN11 is unique due to its highly significant correlation with sensitivity to DDAs. 22 Although the mechanisms of SLFN11-mediated cell killing are not fully understood, two functions of SLFN11 are most likely.

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