Plasma cell-free DNA 5-hydroxymethylcytosine and whole-genome sequencing signatures for early detection of esophageal cancer.

The diagnostic score showed an increasing trend from HC to ESCC, and the scores in stage 0 and I patients were significantly higher than those in HC ( P values = 1.10 × 10 −2 and 3.31 × 10 −5 , respectively, Fig. 4F ), implying the integrated model had great potentials for ESCC early diagnosis.

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