Neuronal-type-specific epigenome editing to decrease <i>SNCA</i> expression: Implications for precision medicine in synucleinopathies.

9 , 10 , 11 , 12 Genetic studies including genome-wide association studies (GWASs) for the most common synucleinopathies, PD and DLB, have implicated SNCA gene, which encodes the α-synuclein protein, as a highly significant genetic risk factor for these diseases. 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 Although the precise mechanisms underlying the associations of SNCA with PD and DLB are yet to be discovered, accumulating evidence suggests that overexpression of SNCA may play a crucial role in etiology of these diseases (reviewed in Tagliafierro and Chiba-Falek 25 ).

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