Augmented Concentration of Isopentyl-Deoxynyboquinone in Tumors Selectively Kills NAD(P)H Quinone Oxidoreductase 1-Positive Cancer Cells through Programmed Necrotic and Apoptotic Mechanisms.

However, at super-lethal IP-DNQ doses (0.4, 0.6, and 0.8 μM), NAD + consumption was rapid and exceeded the available supply within 5 min, causing PAR formation to exhibit a decreasing trend under these conditions ( Figure S2 ).

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