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The primary prevention of birth defects: Multivitamins or folic acid?

Int J Med Sci · 2004 · PMC1074510 · PMID 15912190

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a decreasing trendno p-value reported
The Hungarian randomized clinical trial has also demonstrated that the risk for CAs of cardiovascular system and urinary tract was reduced significantly, in addition limb reduction CAs and congenital pyloric stenosis showed a decreasing trend after the periconceptional multivitamin supplementation 3 - 5 .

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