Beta Blockers Improve Prognosis When Used Early in Patients with Cardiogenic Shock: An Analysis of the FRENSHOCK Multicenter Prospective Registry.

By contrast, the discontinuation of BB therapy was associated with an increase in 1-month mortality and an increasing trend in 1-year all-cause mortality.

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Discussion Based on the largest European prospective, observational, multicenter registry on CS from a wide spectrum of etiologies, we showed several points: (1) the use of BBs within 24 h of CS did not increase 1-month and 1-year all-cause mortality; (2) BB continuation in the early period of CS was not associated with increased short- and long-term mortality, but rather, BB discontinuation was associated with increased 1-month all-cause mortality; (3) early (≤24 h) BB introduction did not significantly improve prognosis but still had a positive trend; and (4) patients treated with BBs within 24 h of CS generally had less severe prior cardiomyopathy and less severe forms of CS.

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