Vertical transmission of maternal DNA through extracellular vesicles associates with altered embryo bioenergetics during the periconception period.

Specifically, we found a 3.2-fold enrichment in mtDNA copy number in MVs in the receptive compared to the pre-receptive period and a 2.6-fold enrichment in the post-receptive compared to the pre-receptive period ( Figure 3C ); however, these changes failed to reach significance.

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