Characterization of genetic humanized mice with transgenic HLA DP401 or DRA but deficient in endogenous murine MHC class II genes upon Staphylococcus aureus pneumonia.

40 In this study, a decreasing trend was observed for the ratio of CD4 + to CD8 + in the lungs of HLA DRA mice before and after intranasal exposure to S. aureus Newman.

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We also observed the significant increase in IL‐6 mRNA (Figure 2C ), MCP‐1 mRNA (Figure 2D ), and MIP‐2 mRNA (Figure 2E ) in WT mice, whereas MCP‐1 mRNA (Figure 2D ) and MIP‐2 mRNA (Figure 2E ) in DRA‐IAβ −/− mice at 1 dpi showed an increasing trend but without statistic significances.

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