highly significantP-value < 1.0E-50
To assess the statistical significance of the enrichment of cLD in 3D contact regions, we conducted Mantel-Haenszel and Fisher exact tests ( Section 3.4 in S1 Text ), both of which are highly significant (P-value < 1.0E-50; Tables J and R and Section 3.4.1 in S1 Text ).