marginally significantP -value = 0.01829
We also found that CGIs on the X Chromosome are more highly methylated compared with autosomal CGIs in both male and female liver tissues (Kruskal–Wallis χ 2 = 17.494, df = 3, P -value = 0.0005592), and similar, marginally significant trends were observed in other tissues (muscle: Kruskal–Wallis χ 2 = 16.864, df = 7, P -value = 0.01829; gonad: Kruskal–Wallis χ 2 = 9.4642, df = 3, P -value = 0.02372) ( Supplemental Fig. 6 ).