Nicotinic acetylcholine receptor signaling maintains epithelial barrier integrity.

We agree that this is a very interesting question, and we have now performed various additional studies to explore the role of nAchR signaling in ISC to EE differentiation: – To confirm our nAchR α2 MARCM data, we utilized the esgF/O strategy (Jiang et al., 2009) to knock down the expression of other subunits in clones via RNAi and observed a mild trend towards fewer EEs in α2 and α4 knockdowns (Figure 2 —figure supplement 2F).

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In both cases, there was a weak trend towards reduced EE differentiation.

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