Metabolites in the regulatory risk assessment of pesticides in the EU.

Front Toxicol · 2023 · PMC10770266 · PMID 38188093

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may be significantno p-value reported

Regarding CYP activity in extrahepatic tissues, although the gut is more restricted in its biotransformation capacity in terms of enzymes and their activities, its contribution as the first-pass site may be significant, e.g., for CYP3A4/5 substrates ( Kato, 2008 ).

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