Furthermore, the blood glucose levels of iHMGB1 KO TMX STZ mice peaked and began to decline between 30 and 45 min post-administration, while HMGB1 Flox TMX STZ mice displayed a decreasing trend in blood glucose levels much later, at a time range between 60 and 120 min post-administration ( Fig. 3 E).
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Restoring glucose balance: Conditional HMGB1 knockdown mitigates hyperglycemia in a Streptozotocin induced mouse model.
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