Phosphatidate phosphatase Lipin1 involves in diabetic encephalopathy pathogenesis via regulating synaptic mitochondrial dynamics.

In addition, PS levels were significantly decreased in the HG + LV-Ctrl group versus both the LV-Ctrl and HG + LV-Lipin1 groups, while a tendency for a decrease was observed between the LV-Lipin1ShRNA and LV-Ctrl groups, but this difference failed to achieve significance ( Fig. 7 E). 3.9 Lipin1 regulates mitochondrial dynamics and maintain mitochondrial function in PC12 cells As phospholipid components, the main content of mitochondrial membranes, were significantly altered by changes in Lipin1 expression, we then investigated the effect of Lipin1 on mitochondrial morphology and function among these four groups.

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