Sound conditioning strategy promoting paracellular permeability of the blood-labyrinth-barrier benefits inner ear drug delivery.

The fraction of parallel TJs was highly significant immediately after SC but not 24 h post‐SC, suggesting that the vascular leakage above was attributed to ultrastructural TJ abnormalities. 3.6 Rab13 inhibits the recruitment of ZO‐1 The protein expression of Rab13 in SV was shown to increase after the SC‐induced BLB permeability enhancement and TJ breakdown (Figure 6a,b ).

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