This result shows a decreasing trend in the risk of irAEs probably due to the T allele dosage effect as confirmed in the allelic model (RR = 0.70; 95% CL 0.48-1.01), as shown in Table 3 .
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The predictive and prognostic role of single nucleotide gene variants of PD-1 and PD-L1 in patients with advanced melanoma treated with PD-1 inhibitors.
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