Needle biopsy accelerates pro-metastatic changes and systemic dissemination in breast cancer: Implications for mortality by surgery delay.

An initial lag-phase of 43 days without a detectable increase in mortality risk shifted to an increasing trend in risk thereafter, reaching significance at 53 days, and was followed by a second phase of exponential increase in mortality risk ( Figure 1 A), with 6%, 29%, 66%, and 117% higher mortality risk for patients who had a biopsy-to-surgery interval of 60, 90, 120, and 150 days, respectively, compared to the reference group who waited only 30 days for surgery ( Figure 1 B).

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