FcγRIIb Exacerbates LPS-Induced Neuroinflammation by Binding with the Bridging Protein DAP12 and Promoting the Activation of PI3K/AKT Signaling Pathway in Microglia.

Moreover, the expression of DAP12 was significantly increased in the cerebral cortex of LPS-injected mice ( Figure 1C ), while the expression in LPS-stimulated BV2 cells also showed an increasing trend ( Figure 2C ).

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The q-PCR assay results were consistent with the ELISA results, in that expression knocking-down of FcγRIIb in BV2 cells significantly inhibited the expression of inflammatory factors in LPS stimulated group, and the expression levels of TNF-α, IL-6, and IL-1β showed a decreasing trend.

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