Mechanism-centric regulatory network identifies NME2 and MYC programs as markers of Enzalutamide resistance in CRPC.

Nat Commun · 2024 · PMC10774320 · PMID 38191557

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borderline significantno p-value reported

Furthermore, Cox proportional hazards model analysis 38 indicated that five of the transcriptomic markers ( STMN1, WDR12, AZIN1, MAD2L1 , and MCM4 ) had a significant association with response to Enzalutamide (Wald p value < 0.05, Supplementary Data 5C , see Methods), yet many of them were borderline significant and did not outperform MYC and NME2 (Supplementary Data 7C ).

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