Cross-sectional analysis of healthy individuals across decades: Aging signatures across multiple physiological compartments.

When examining 92 age‐associated metabolites, the correlation between the age beta coefficient was highly significant ( r = 0.79, p = 2.2e‐16; Figure S2B ), suggesting the reliability of our method. 91 of them changed with age in the same direction, among which 27 were statistically significant.

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The age‐associated decline of BCAA catabolism observed in urine and borderline significance in plasma ( p = 0.056) may be an indication of a decline in mitochondrial biogenesis and reduced energy production (Esterhuizen et al., 2017 ).

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