Recently, a pan-cancer analysis using DNA sequencing data from over 40,000 patients showed that SEC62 gene amplification represents a highly significant indicator of poor overall survival [ 21 ].
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Expression of 3q Oncogene SEC62 Predicts Survival in Head and Neck Squamous Cell Carcinoma Patients Treated with Primary Chemoradiation.
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Regarding a potential correlation between SEC62 expression and response to treatment according to RECIST 1.1 criteria, no significant difference in SEC62 levels was seen between patients with complete remission (CR), partial remission (PR), stable disease (SD), and progressive disease (PD), with only a slight trend towards lower SEC62 levels in CR patients compared to non-CR patients (PR + SD + PD; Figure 1 F).