The CFR may be significant among these infections, such as 18% for WNV encephalitis 29 and 20% for JE. 30 The CFR following TBE depends on the viral subtype: the Far East subtype is known to be more pathogenic than the Siberian and European subtypes, with the CFR following TBE due to the European subtype reportedly being less than 1%. 31 Flaviviruses share a common neurotropism for the thalamus, basal ganglia, brainstem, and anterior horn cells of the spinal cord. 32 , 33 Their clinical presentation and outcomes consequently share common features and sequelae, although there also are some differences.
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