Interactions of genetic variations in FAS, GJB2 and PTPRN2 are associated with noise-induced hearing loss: a case-control study in China.

Seven SNPs in six genes ( CDH23 rs2394795, FAS rs1468063 and rs2862833, GJB2 rs3751385, HOTAIR rs87494, SIK3 rs6589574, STAT3 rs1053005) were found to be significantly different between two groups under at least one genetic model ( p < 0.05; Supplementary Table 3 ), and eight SNPs in seven genes ( FOXO3 rs2802292 and rs10457180, GAPDH rs6489721, HDAC2 rs10499080, hOGG1 rs1052133, PTPRN2 rs10081191, STAT3 rs1053023 and TAB2 rs521845) were marginally significant (0.05 < p < 0.10; Supplementary Table 3 ).

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It is now generally believed that replication of findings in several independent sample sets is more important than to obtain highly significant p values [ 24 ].

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Two-tailed p < 0.05 indicated statistical significance, and 0.05 < p < 0.10 was marginal significance.

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