Notably, highly significant enrichment of the HOXA5 targets and the target genes of NUP98-HOXA9 fusion for the increased genes in RBM5 OE, further suggesting a correlation between RBM5 and HOXA9 (Fig. 5 c).
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RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9.
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