Analysis of the proteome by LC-MS/MS in these cultures showed that blocking the proteasome indeed caused a highly significant accumulation of peptides with heavy intensities as well as all peptides assessed by both heavy and light intensities ( Figure S2C ), further validating this experimental paradigm.
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Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis.
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