FGFR inhibition augments anti-PD-1 efficacy in murine FGFR3-mutant bladder cancer by abrogating immunosuppression.

In a per-signature analysis, UPFL tumors were significantly enriched, as compared with UPPL tumors, for numerous subsets of T cells, including CD8 + , central memory, and effector memory, while trending toward significance for T follicular helper cells and γδ T cells (Bindea) ( Figure 4, C–G ), the latter of which are important for adaptive immunity at mucosal surfaces ( Figure 4G ).

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