Biologically informed deep learning for explainable epigenetic clocks.

Interestingly, the predicted biological age of the negative control cells shows a positive trend in time, consistent with the recent findings by Levine et al. 41 .

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The top features where an increasing trend was observed in the z -score consisted of the Transport of small molecules (R-HSA-382551), Extracellular matrix organization (R-HSA-1474244) and a general pathway category called Disease (R-HSA-1643685).

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