Predictors of Kidney Function Outcomes and Their Relation to SGLT2 Inhibitor Dapagliflozin in Patients with Type 2 Diabetes Mellitus Who Had Chronic Heart Failure.

Although there is strong evidence that elevated NT-proBNP levels predict poor clinical outcomes in elderly patients with chronic HF within 90 days of acute kidney injury onset and a decreasing trend in the NT-proBNP levels is associated with a lower risk of cardiovascular mortality [ 62 ], we did not notice that dynamic changes in NT-proBNP better predicted kidney outcomes in diabetic patients with stable chronic HF than the levels of this biomarker at baseline.

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These findings require some explanation, perhaps related to the fact that all acute inflammatory phase cytokines showed an increasing trend up to the end of the acute injury stage, stabilizing or declining thereafter [ 63 ].

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