During the multi-county 2022 MPX outbreak, a highly significant association with HIV was noted, with the United States Centers for Disease Prevention and Control reporting a HIV co-infection rate of 46% in MPX cases and an HIV prevalence of 28–47% in other countries’ reports among patients with MPXV infection ( 4 , 13 , 15–18 ).
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Cases of Monkeypox show highly-overlapping co-infection with HIV and syphilis.
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