Down-regulation of insulin receptor in DSS-induced chronic colitis Among the pairs screened by DEmRNA and DElncRNA joint analysis, both INSR and the INSR-regulating lncRNA, MSTRG.175050.1, showed highly significant down-regulated fold changes in colitis (INSR top10, MSTRG.175050.1 top30, Additional file 1: Table S1).
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Activation of mucosal insulin receptor exacerbates intestinal inflammation by promoting tissue resident memory T cells differentiation through EZH2.
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