The beneficial effect of prophylactic hydrocortisone treatment in extremely preterm infants improves upon adjustment of the baseline characteristics.

After adjusting for the patient’s probability of BPD-free survival using baseline predictors alone, the HC treatment exhibited a highly significant effect (OR [95% CI] = 2.053 [1.602–2.501], p = 0.002), with a number needed to treat NNT [95% CI] = 5.8 [4.1–23.0].

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