Differential diagnosis of mild cognitive impairment of Alzheimer's disease by Simoa p-tau181 measurements with matching plasma and CSF.

We speculate the cause for this difference is that our Aβ-positive aMCI group (aMCI A+ in Figure 3 ) contains both total tau negative or total tau positive cohorts, and highly significant elevation in p-tau181 levels in Aβ− and total tau-double positive aMCI cases vs. cognitively normal group compensated for the very little elevation in p-tau181 levels in Aβ-positive and total tau-negative aMCI cohorts vs.

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