Association of clinicopathologic and molecular factors with the occurrence of positive margins in breast cancer.

The bi-variable survival models (Table 5 ) demonstrated that margin status remained highly significant when PAM50 or either of the hormone receptor (ER/PR) status was added to the model whereas in the model with tumor stage, margin status was only close to significance ( p = 0.067).

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Tumor stage, size, and lymph node status, which were highly significant in the univariable model, were no longer significant in the multivariable model (Supplementary Table S1).

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