Previously studies have shown a decreasing trend of TILs in metastatic/recurrent breast cancer compared to primary breast cancer, 15 , 26 , 33 , 34 and we also found this decreasing trend both in the peritumor and stroma of locoregional recurrent tumors.
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Immune cells within tertiary lymphoid structures are associated with progression-free survival in patients with locoregional recurrent breast cancer.
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