Protein interaction networks characterizing the A549 cells Klotho transfected are associated with activated pro-apoptotic Bim and suppressed Wnt/β-catenin signaling pathway.

Finally, the WM55-2 (turquoise-2) module consisting of 582 member proteins was identified as by far the most highly significant to the A549/KL trait ( r = 0.97 and q value = 8.22 × 10 −11 ) (Fig. 3 B).

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