The effect and mechanism of Fushen Granule on gut microbiome in the prevention and treatment of chronic renal failure.

Compared to rats before FMT, the model + saline group, the model + Fushen Granule Donor group, and the model + normal Donor group showed a decreasing trend for Firmicutes bacteria and an increasing trend for Bacteroidetes.

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Compared with the sham-operated group in the same period, CRF rats had a decreased abundance of the firmicutes phylum and an increased abundance of the bacteroidetes phylum at the phylum level, and a decreasing trend of the lactobacillus genus at the genus level.

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