Alzheimer's-specific brain amyloid interactome: Neural-network analysis of intra-aggregate crosslinking identifies novel drug targets.

Target-based in silico screening of small-molecule structural libraries predicted several that specifically target GFAP; the best candidate was validated in several AD-model systems wherein we observed highly significant reductions in aggregate burden. 5 , 21 The approach, strategies, and more importantly the influential proteins, described here can be generalized to many other neurodegenerative diseases that feature age-associated protein aggregation as hallmarks.

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