Flavonoid Rutin Presented Anti-Glioblastoma Activity Related to the Modulation of Onco miRNA-125b Expression and STAT3 Signaling and Impact on Microglia Inflammatory Profile.

We observed that GBM cells express and secrete miRNA-125b, and the treatment with rutin induces a highly significant reduction in the levels of this miRNA at both intracellular (** p < 0.002) and secretome (* p < 0.02), compared with control cultures ( Figure 2 ). 2.3.

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