Age-stratified kidney outcomes were unavailable in this paper; however, overall, GLP1-RAs were associated with a favorable effect on the composite kidney outcome (21%reduction (HR 0.79 [95% CI 0.73–0.87]; p < 0.0001)), with a favorable trend for the worsening kidney function outcome (14% reduction (HR 0.86 [95% CI 0.72–1.02])).
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The sentences
These worrisome trends are not US specific; the International Diabetes Federation Atlas [ 16 ] projects an increasing trend of DM up to 2045.