Stereotactic Radiosurgery in the Management of Brain Metastases: A Case-Based Radiosurgery Society Practice Guideline.

9 More recently, a UT—MD Anderson trial comparing SRS to WBRT in patients with 4 to 15 metastases demonstrated improved neurocognitive function, numerically improved OS, comparable local control, and a nonsignificant trend toward inferior overall intracranial control, though it is important to note that this trial was terminated early and has only been published in abstract form. 10 Therefore, prospective evidence supports treatment of up to 15 lesions with SRS, although many centers consistently treat larger numbers of lesions with apparent safety.

also in 5,406 other papers