These analyses ultimately identified seven highly significant genes (CTSL, NPL, CPVL, APOE, TTYH3, S100A9, and PLA2G7), supported by 1000-fold cross-validation ( figure 1H ).
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Inhibiting PLA2G7 reverses the immunosuppressive function of intratumoral macrophages and augments immunotherapy response in hepatocellular carcinoma.
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