A significant decrease in the eradication rate worldwide, along with an increasing trend of H. pylori antibiotic resistances warrants more specific approach to H. pylori eradication therapy, utilizing antimicrobial stewardship. 145 Given that antibiotic resistance patterns differ according to geographic regions, it is recommended to use treatment regimens that are locally effective according to regional susceptibility patterns. 87 , 145 , 146 However, many regions lack reliable data on the prevalence and characteristics of antibiotic resistance in local populations to guide the selection of empirical eradication therapy.
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Antibiotic Resistance of <i>Helicobacter pylori</i>: Mechanisms and Clinical Implications.
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