Cycloheximide, a protein translation inhibitor that only slightly extends lifespan [ 47 , 48 ], also showed a decreasing trend, which is quite evident on day 5 of adulthood (Fig. 2 A, S2 B).
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In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes.
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