Early cerebral amyloid-β accumulation and hypermetabolism are associated with subtle cognitive deficits before accelerated cerebral atrophy.

We observed a borderline significant correlation between PiB SUVr and worse performance on PAL ( p = 0.066) and a significant correlation between increased PiB SUVr and more decline in PAL score ( p = 0.032) (Table 2 ), demonstrating that participants who did not maintain cognitive performance had increased A β deposition (Fig. 4 b) (Table 2 ).

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