Inactivation of phosphodiesterase-4B gene in rat nucleus accumbens shell by CRISPR/Cas9 or positive allosteric modulation of the protein affects the motivation to chronically self-administer nicotine.

Sci Rep · 2024 · PMC10831042 · PMID 38297069

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highly significantno p-value reported

Similarly, for nicotine infusions, the main effects of day (F 33,814 = 11.0, p < 2e−16) and FR schedule (F 4,100 = 26.0, p = 8.8e−15) were highly significant.

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