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Heart Failure Guideline-Directed Medical Therapy in End-Stage Kidney Disease: From PARADIGM-HF to Clinical Practice.

Kidney Int Rep · 2024 · PMC10831360 · PMID 38312787

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3 In PARAGON-HF, which enrolled patients with HF and preserved ejection fraction, sacubitril/valsartan narrowly missed statistical significance for its primary end point. 4 However, a subgroup analysis suggested potential benefits in subjects with below-normal left ventricular ejection fraction.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.